Toxic Action Data for the Mixture of Concern and Component Mixtures
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چکیده
This chapter provides a review and evaluation of the literature pertinent to joint toxic action of the mixture and its components. The text is generally organized so that human data are presented first, and studies are grouped by route, and by endpoint where that is feasible. In Section 2.2, summary tables are provided at the end of each section on the binary mixtures. The tables are designed to provide an overview of the direction of interaction. The organization of the tables is by route, duration, and endpoint of toxicity so that all data for an endpoint of concern for a given route and duration are grouped together. The organization of the summary tables is designed to promote a synthesis of the data across studies and an understanding of the potential route, duration, and endpoint-specificity of the direction of interaction.
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2. Joint Toxic Action Data for the Mixture of Concern and Component Mixtures
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This chapter provides a review and evaluation of the literature pertinent to joint toxic action of the mixture and its components. 2.1 Mixture of Concern Toxicological data or PBPK models were not available for the complete mixture of concern. Toxicological and mechanistic data, but no PBPK models, were available for all of the binary mixtures, but were limited. For some binary mixtures, few or...
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